Hence an attempt has been made to evaluate the antiulcer activity of leea indica. A total of 31 compounds of different classes, including benzoic acid derivatives, phenolics, flavonoids. Effects of organic extracts of six bangladeshi plants on in. Since there are no reports on the chemistry and antimicrobial activity of essential oil of its flowers the present study was taken up. In the present study, leea indica was selected for the evaluation of its anti tumor potential against eac cell line. Friedelcraft condensation reaction has been used to prepare anthraquinone backbone in view of its less stringent requirements with regards to reaction conditions such as humidity, highly reactive reagents and lower cost.
It is seen as common undergrowth in secondary and disturbed evergreen forests in indomalaya, indochina, australia and pacific islands and throughout in the western ghats of india. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels. Antihyperglycemic and hypolipidemic activity of leea indica. Phytochemical values namely total phenolic and flavonoid contents, total antioxidant capacity, dpph radical scavenging effect, fecl 3 reducing power, dmso superoxide scavenging effect and iron chelating effects were studied by established. Familyleeaceae is widely spread in medicinal insect in treatment of common fever. Identification of chemical compounds from the leaves of. Leea indica ethyl acetate fraction induces growthinhibitory effect in various cancer cell lines and apoptosis in ca ski human cervical epidermoid carcinoma cells. Twentythree known chemical compounds were identified in the leaves of leea indica burm. Department of agriculture agricultural research service. They inhibited the growth of ca ski cervical cancer cells with ic 50 of. Chemical composition and antimicrobial activity of the. Antioxidative, antimicrobial and cytotoxic effects of the. Sedative and anxiolytic effects of the methanolic extract of.
Herbal preparations have been used since ancient times for the treatment of several diseases although they show little toxicity. The crude ethanol extract and fractions ethyl acetate, hexane, and water of leea indica were evaluated their cytotoxicity on various cell lines ca ski, mcf 7, mdamb435, kb, hep g2, wrl 68, and vero by mtt assay. Merr leeaceae, is a large evergreen shrub native to tropical india, bangladesh, china, bhutan, and malaysia. Effects of organic extracts of six bangladeshi plants on. In vitro antioxidant and anticancer activity of leea indica leaf extracts on human prostate cancer cell lines. According to acute toxicity study the plant extract was found to be safe upto 2000mg kg. Herbal preparations have been used since ancient times for the treatment of. Leea contains approximately 70 species and is placed in the vitaceae family. Phenolic content, antioxidant effect and cytotoxic activity of leea indica leaves article pdf available in bmc complementary and alternative medicine 121. A team of researchers from the national university of singapore has recently discovered that the bandicoot berry leea indica, south african leaf vernonia amygdalina and simple leaf chastetree. Leea indica in the germplasm resources information network grin, u. Aqueous fruit extract were added to 1 mm silver nitrate. It usually grows from 2 10 metres tall, occasionally to 16 metres, with stems around.
Identification of phytoconstituents in leea indica burm. The sedative and anxiolytic potential of leea indica burm. Family leeaceae is an evergreen perennial shrub with stout, soft wooded, glabrous stems indigenous to tropical asia, australasia, pacific and grown. Phenolic content, antioxidant effect and cytotoxic.
With more than 1,000 strains of cannabis having been bred during the past several decades, it is critical that patients are aware of the different types of efficacy available to them in terms of cannabis medicine. Research article open access phenolic content, antioxidant effect and cytotoxic activity of leea indica leaves nidyaletchmy subba reddy1, suerialoasan navanesan1, saravana kumar sinniah1, norhanom abdul wahab2 and kae shin sim1 abstract background. Two cycloartane triterpenoid glycosides, mollic acid arabinoside maa and mollic acid xyloside max, were firstly isolated from l. Thrombus formed in blood vessels lead to atherothrombotic diseases such as myocardial or cerebral infarction. The apg iv system places leea in the subfamily leeoideae vitaceae. The record derives from tropicos data supplied on 20120418 which reports it as an accepted name record 34000941 with original publication details. Leea indica ethyl acetate fraction lieaf was found. Leaves of leea indica have multiple pharmacological activities like antitumour. The identified compounds include eleven hydrocarbons, phthalic acid, palmitic acid, 1eicosanol, solanesol. In vitro antioxidant and anticancer activity of leea. The insect is actually used in the form decoction10. Shrub or small tree, 15 m tall, stem warted or smooth, stipules fused with the petiole and encircling the stem.
Hence the doses selected for the study was 15th and 110th of the toxic dose 200mgkg, 400mgkg. Phenolic content, antioxidant effect and cytotoxic activity. In the present investigation fruit extract of leea indica burm. The leaves of leea indica vitaceae, commonly known as huo tong shu in malaysia, have been. A total of 31 compounds of different classes, including benzoic acid derivatives. Botanical descriptions ecology distribution literatures. Anticancer effect of marine spongeassociated bacillus. The present study was initiated to identify a novel cytotoxic bioactive molecule from marine sponge callyspongia fistularis symbionts and to investigate its apoptotic role on human liver cancer cell line hepg2. Six plants native to southeast asia show cancerfighting. Green nanotechnology is gaining importance due to the elimination of harmful chemicals and provides a safe, environmental friendly and economic method for synthesis of nanoparticles. Evidencebased complementary and alternative medicine hindawi.
Anti ulcer activity of leea indica in wistar albino rats. Research article open access phenolic content, antioxidant. The current study reports the outcome of antioxidant and cytotoxic investigation of l. Pdf antioxidant, cytotoxic and phytochemical properties of. Damnacanthal and nordamnacanthal were synthesized due to their interesting property as cytotoxic agents against several cancer celllines. Aug 17, 2012 the leaves of leea indica vitaceae, commonly known as huo tong shu in malaysia, have been traditionally used as natural remedy in folk medicine by the locals. Leea indica, a traditional chinese medicinal plant is the sole member of the family leeaceae, which is closely related.
The antioxidant activity of the extracts correlated well with the total phenolic contents and indicated that phenolic compounds are dominant contributors to the antioxidant activity of the extracts. The leaves of leea indica vitaceae, commonly known as huo tong shu in malaysia, have been traditionally used as natural remedy in folk. Files are available under licenses specified on their description page. Leea robusta blume leea roehrsiana sanders ex masters.
Phenolic content, antioxidant effect and cytotoxic activity of leea. Leeaceae by gcms analysis, spectroscopic techniques and cotlc with authentic samples. This study investigated the phytochemical, antioxidative, antimicrobial and cytotoxic effects of leea indica leaf ethanol extract. Media in category leea indicathe following 77 files are in this category, out of 77 total. Media in category leea the following 31 files are in this category, out of 31 total. Leea indica might have elicited antiulcer activity owing to the presence of saponins, flavonoids and tannins. Pdf antioxidant, cytotoxic and phytochemical properties. The leaves of leea indica vitaceae, commonly known as huo tong shu in malaysia, have been traditionally used as natural remedy in folk medicine by the locals. Leea indica ethyl acetate fraction induces growthinhibitory effect. Evidencebased complementary and alternative medicine.
Anticandida albicans activity of crude extract of the local plant, winged beans leaf. Leea indica, the bandicoot berry, is a large shrub in the family vitaceae. According to the website of american diabetes association type 2 diabetes is the most common form of diabetes, in type 2 diabetes, either the body does not produce enough insulin or the cells ignore. Dec 24, 2014 this page was last edited on 14 september 2017, at 20. Leea indica is an erect shrub to small tree, often with several stems. This study was designed to investigate the phenolic content, antioxidant effect and cytotoxic activity of l. Talyantan is a genus of plants that are distributed throughout northern and eastern australia, new guinea, south and southeast asia and parts of africa. Pdf traditional uses, chemistry and pharmacological activities of. Pdf phenolic content, antioxidant effect and cytotoxic. The extracts of all the isolated strains amk1amk12 from sponge callyspongia fistularis were screened based on cytotoxicity on hepg2 cell line, among. Leea indica is a medicinal plant used traditionally to cure cancer.
It usually grows from 2 10 metres tall, occasionally to 16 metres, with stems around 19cm in diameter. Leea indica ethyl acetate fraction lieaf was found showing the greatest cytotoxic effect against. Antibacterial activity of root, stem and leaf extracts of l. Mali, leea indica, bandicoot berry herbal medicine an illustrated compilation of philippine medicinal plants by dr godofredo umali stuart with botanical information, chemical properties, folkloric uses and medicinal research studies. Media in category leea indica the following 77 files are in this category, out of 77 total. Sedative and anxiolytic effects of the methanolic extract. It is seen as common undergrowth in secondary and disturbed evergreen forests in indomalaya, indochina, australia and pacific islands and.
Pdf plants have been used for various purposes of humans. Aqueous fruit extract were added to 1 mm silver nitrate solution by changing the colour of reaction mixture from colourless to brown colour indicates the formation of silver nanoparticles further, confirmed by. Habitat grows in disturbed lowland and upland rainforest distribution occurs in the cape york peninsula, north east queensland and south to coastal central queensland. All structured data from the file and property namespaces is available under the creative commons cc0 license.
Validated high performance thin layer chromatography. Identification of chemical compounds from the leaves of leea. Densitometric chromatogram of hydrolysed methanol extract of leea indica a, reference standards gallic acid b and quercetin c scanned at 254 nm. Leea indica is a well known plant with numerous pharmacological activities owing to the presence of the active constituents. The anticancer potential of leea indica, a chinese medicinal plant was investigated for the first time. Aug 31, 2017 in this paper, we investigate the potency of leea indica locally known as memali plant from tasik chini, pahang as a potent antioxidant and antimicrobial agent. In this paper, we investigate the potency of leea indica locally known as memali plant from tasik chini, pahang as a potent antioxidant and antimicrobial agent. Leea sambucina, leea staphylea 7, commonly known as chhatri in sanskrit 6, is a large evergreen perennial shrub growing up to 23 m in height with stout, soft. Identification of chemical compounds from the leaves of leea indica. May, 2019 a team of researchers from the national university of singapore has recently discovered that the bandicoot berry leea indica, south african leaf vernonia amygdalina and simple leaf chastetree. This name is the accepted name of a species in the genus leea family vitaceae the record derives from. In vitro antioxidant and anticancer activity of leea indica. Pdf ethnobotany and phytopharmacology of leea indica. Evaluation of antitumor activity of leea indica burm.
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